Arik Shams

CRISPR, genome engineering, science policy, biotech, bioethics, 🇧🇩

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• Shams A, Higgins SA, Fellmann C, Laughlin TG, Oakes BL, Lew R, Kim S, Lukarska M, Arnold M, Staahl BT, Doudna JA, Savage DF. Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules. Nat Commun. 2021 Sep 27;12(1):5664.

• Jiang F, Takagi Y, Shams A, Heissler SM, Friedman TB, Sellers JR, Bird JE. The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness. J Biol Chem. 2021 Jan-Jun; 296:100243. doi: 10.1074/jbc.RA120.014903. Epub 2021 Jan 9.

• Moreland ZG, Jiang F, Aguilar C, Barzik M, Gong R, Shams A, Faaborg-Andersen C, Werth JC, Harley R, Sutton DC, Cole SM, Parker A, Morse S, Wilson E, Takagi Y, Sellers JR, Brown SDM, Friedman TB, Alushin GM, Bowl MR, Bird JE. Myosin-based nucleation of actin filaments drives stereocilia development critical for hearing. Sci Adv. In review. 2022.

• Iverson D, Serrano C, Brahan AM, Shams A, Totsingan F, Bell AJ Jr. Characterization of the structural and protein recognition properties of hybrid PNA-DNA four-way junctions. Arch Biochem Biophys. 2015 Dec 1; 587:1-11. doi: 10.1016/j.abb.2015.08.017. Epub 2015 Sep 5.

• Iverson D, Serrano C, Brahan AM, Shams A, Totsingan F, Bell AJ Jr. Supporting data for the characterization of PNA-DNA four-way junctions. Data Brief. 2015 Oct 22; 5:756-60. doi: 10.1016/j.dib.2015.10.013.